Brian Amsden PhD, P.Eng

Professor & Associate Vice-Principal of Research

Faculty, Chemical Engineering
Phone: 613-533-6000 ext. 33093
Biosciences Complex, Room: 4632


Expertise: Controlled release, Diffusion in gels and polymer solutions, Polymer biomaterials, Protein drug delivery, Tissue engineering
Brian Amsden
Biography Research Teaching Publications Awards & Grants

Brian Amsden is the Donald and Joan McGeachy Chair in Biomedical Engineering at Queen’s University. Following the completion of his PhD (Queen’s 1996), he worked for Angiotech Pharmaceuticals in Vancouver as a Research Associate, leading projects involving the formulation of paclitaxel for localized delivery to treat restenosis, psoriasis, and rheumatoid arthritis. He left Angiotech to join the Faculty of Pharmacy at the University of Alberta in 1997 and is currently a Professor in the Department of Chemical Engineering at Queen’s University where he has been since July 2000.

Our research focus is on the creation of effective biodegradable and biocompatible polymers for biomedical applications. These applications include localized growth factor delivery for therapeutic angiogenesis and for stem cell differentiation, scaffolds for soft connective tissue engineering, and ocular drug delivery. Polymer systems being developed include biodegradable elastomers, electrospun crimped fibre scaffolds, injectable thermoplastics, and mechanically enhanced hydrogels. We are interested in elucidating the mechanisms of degradation of the polymers in vivo to better design these materials for given applications, determining the mechanisms governing drug release, the role polymer biomaterial mechanical properties play in mediating cell proliferation and differentiation, and in controlling polymer surface properties to improve cellular interactions. The work is multidisciplinary and we collaborate routinely with orthopaedic and cardiovascular surgeons, and colleagues in mechanical engineering and cell biology.

CHEE 452: Transport Phenomena in Physiological Systems

This course is an introduction to the area of mass, momentum and heat transfer processes in physiological systems. In this course the student will appreciate the role of transport phenomena in the function of organs and organ systems in the body, and develop the skills necessary to analyze models of biological transport processes in the context of the design of biomedical devices. (0/0/0/42/0)

CHEE 872: Polymer Biomaterials

This is an advanced biomaterials course focusing on polymers used in biomedical applications. Topics covered include composition-property relationships of polymers, the host implantation response, controlled release mechanisms, biodegradation of polymers, and cell-polymer interactions.

Journal Publications

BG Amsden, Degradation mechanisms of aliphatic polycarbonates and functionalized aliphatic polycarbonates, Invited Review for Macromolecular Bioscience, 21 (2021) 2100085

  1. Mohajeri and BG Amsden, In vivo degradation mechanism and biocompatibility of a biodegradable aliphatic polycarbonate: poly(trimethylene carbonate-co-5-hydroxy trimethylene carbonate), ACS Applied Bio Materials, 4(4) (2021) 3686-3696.
  2. Mohajeri, J. Burke-Kleinman, DH Maurice, BG Amsden, Formulation parameters governing sustained protein delivery from degradable viscous liquid aliphatic polycarbonates, Int J Pharm, 590 (2020) 119965.

Amanda J Brissenden and BG Amsden*, Insights into the polymerization kinetics of thermoresponsive polytrimethylene carbonate bearing a methoxyethoxy side group, J Polym Sci A: Polym Chem, 58 (2020) 2697-2707

  1. Mohajeri, F. Chen, M de Prinse, P Ta, J Burke-Kleinman, DH Maurice and BG Amsden*, “Liquid degradable poly(trimethylene-carbonate-co-5-hydroxy-trimethylene carbonate): an injectable drug delivery vehicle for acid-sensitive drugs,” Molecular Pharmaceutics 17 (2020) 1-14.
  2. Taghavi and BG Amsden, “In vivo degradation behavior of enzyme-degradable poly(trimethylene carbonate)-based biohybrid networks of varying water content,” Biomedical Materials 15 (2020) 025001.

Arthi Shridhar, Brian G. Amsden, Elizabeth Gillies, and Lauren E Flynn*, “Investigation of the effects of tissue-specific extracellular matrix on the adipogenic and osteogenic differentiation of human adipose-derived stromal cells within composite hydrogel scaffolds,” Frontiers in Bioengineering and Biotechnology, 7 (2019) 402.

SA Young, H Riahinezhad, BG Amsden*, “In situ-forming, mechanically resilient hydrogels for cell delivery,”Invited Review article J Mater Chem B 7 (38), 5742-5761.

L Davenport Huyer, D Bannerman, Y Wang, H Savoji, EJ Knee Walden, A Brissenden, B Yee, M Shoaib, E Bobicki, BG Amsden, M Radisic*, “One-pot synthesis of unsaturated polyester bio-elastomer with controllable material curing for microscale designs,” Advanced Healthcare Materials, 1900245, 2019.

  1. Taghavi, A. Brissenden, and BG Amsden, “High modulus, enzyme-degradable poly(trimethylene carbonate)-peptide biohybrid networks formed from triblock prepolymers,” J. Mater Chem B 2019, 7, 2819-2828.
  2. Dhillon, SA Young, SE Sherman, GI Bell, BG Amsden, DA Hess, LE Flynn*, “Peptide-modified methacrylated glycol chitosan hydrogels as a cell-viability supporting pro-angiogenic cell delivery platform for human adipose-derived stem/stromal cells,” J Biomed Mater Res A, 107 (3) (2019) 571-585

SA Young, LE Flynn* and BG Amsden*, “Stem cells delivered in a resilient in situ forming hydrogel for therapeutic angiogenesis,” Tissue Engineering A, 24 (2018) 1784-1797.

F Chen, R. Qi, L Davenport-Huyer, and BG Amsden, “Degradation of poly(5-hydroxy-trimethylene carbonate) in aqueous environments” Polymer Degradation and Stability, 158 (2018) 83-91.

JP Chesterman, TC Hughes, and BG Amsden*, Reversibly photo-crosslinkable aliphatic polycarbonates functionalized with coumarin, Eur. Polymer J, 105 (2018) 186-193.

G Hochleitner, F Chen, C. Blum, P. Dalton, BG Amsden, and J Groll*,”Crimped elastomer scaffolds prepared through MEW with non-linear extension behaviour mimicking that of ligaments and tendons,” Acta Biomaterialia, 72 (2018) 110-120.

SA Young, SE Sherman, TT Cooper, C Brown, F Anjum, DA Hess, LE Flynn* and BG Amsden*, “Mechanically Resilient Injectable Scaffolds for Intramuscular Stem Cell Delivery and Cytokine Release” Biomaterials. 159 (2018) 146-160.

DA Louka, N Holwell, BH Thomas, F Chen, and BG Amsden*, “Highly Bioactive SDF-1α Delivery from Low-Melting-Point, Biodegradable Polymer Microspheres” ACS Biomat Sci Eng 2018, 4 (11), pp 3747–3758.

G Chen, S Taghavi, D Marecak and BG Amsden*, “Tough and enzyme-degradable hydrogels” Macromolecular Materials and Engineering, 2018: 303 (1), 1700162.

JP Chesterman, Amanda Brissenden, Fei Chen and BG Amsden*, “Cinnamoyl and Coumarin Functionalized Polycarbonates” Polymer Chemistry 8 (2017) 7515 - 7528.

F Anjum, A Carroll, S. Young, LE Flynn and BG Amsden*, “Tough semi-synthetic hydrogels for stem cell delivery for chondral defect repair”, Macromolecular Bioscience 17 (5) (2017) 1600373.

JP Chesterman and BG Amsden*, “Triethylamine-based catalysts for the melt polymerization of carbonate monomers,” Polymer Chemistry, 7 (2016) 6946-6953.

BG Amsden* and D Marecak, “Long-term sustained release from a biodegradable photo-cross-linked network for intra-ocular corticosteroid delivery,” Molecular Pharmaceutics, 13(9) (2016) 3004-3012.

JWS Hayami, SD Waldman, BG Amsden*, “Chondrocyte generation of cartilage-like tissue following photoencapsulation in methacrylated polysaccharide solution blends.” Macromolecular Bioscience, 16(7) (2016) 1083-1095.

F Chen, G Hochleitner, T Woodfield, J Groll, P. Dalton, and BG Amsden, “Additive manufacturing of photo-cross-linked structures via melt electrospinning writing,” Biomacromolecules, 17(1) (2016) 277-284.

MC Vyner and BG Amsden, “Polymer chain flexibility-induced differences in fetuin A adsorption and its implications on cell attachment and proliferation” Acta Biomaterialia, 31 (2016) 89-98.

J Yang, F Chen, BG Amsden, “Cell sheets prepared via gel-sol transition of calcium RGD-alginate” Acta Biomaterialia 30 (2016) 277-284.

  1. Chen and BG Amsden*, “Homo- and co-polymerization kinetics of trimethylene carbonate bearing a methoxyethoxy side group.” J Polym Sci A Polym Chem 54 (2016) 544-552.

T.Y. Han, S Toutounji, BG Amsden, LE Flynn*, Adipose-derived stromal cells mediate in vivo adipogenesis, angiogenesis and inflammation in decellularized adipose tissue bioscaffolds,” Biomaterials, 72 (2015) 125-137.

  1. Brown, J Yan, T. Han, D. Marecak, BG Amsden, LE Flynn*, “Effect of decellularized adipose tissue particle size on adipose-derived stem cell proliferation and adipogenic differentiation in composite methacrylated chondroitin sulphate hydrogels,” Biomedical Materials 10 045010, 2015.

BG Amsden, “Novel biodegradable polymers for local growth factor delivery,” invited review for European J Pharm Biopharm 97 (2015) 318-328.

JWS Hayami, SD Waldman, BG Amsden*, “Photo-cross-linked methacrylated polysaccharide solution blends with high chondrocyte viability, minimal swelling, and moduli similar to load bearing soft tissues.” European Polymer Journal 72 (2015) 687-697

N.A. Hadjiev and BG Amsden*, “An assessment of the predictive ability of the obstruction-scaling model of solute diffusion coefficients in hydrogels,” J Controlled Release 199 (2015) 10-16.

MC Vyner, A Li, BG Amsden*, “The effect of poly(trimethylene carbonate) molecular weight on macrophage behavior and enzyme adsorption and conformation,” Biomaterials 35(33) (2014) 9041-9048.

F Chen, JWS Hayami, and B.G. Amsden*, “Electrospun fibrous polymer scaffolds with stabilized crimp-like structure,” Biomacromolecules, 15(5) (2014) 1593-1601.

J Yang, J Yan, Z Zhou, BG Amsden*, “Dithiol-PEG-PDLLA micelles: preparation and evaluation as potential topical ocular delivery vehicle” Biomacromolecules, 15(4) (2014) 1346-1354.

V Russo, S Young, G. Andrew Hamilton, BG Amsden, LE Flynn*, “Mesenchymal stem cell delivery strategies to promote cardiac regeneration following ischemic injury” Biomaterials 35 (2014) 3956-3974.

H.K. Cheung, T. Han, D.M. Marecak, J.F. Watkins, and L.E. Flynn, "Composite hydrogel scaffolds incorporating decellularized adipose tissue for soft tissue engineering with adipose-derived stem cells," Biomaterials 35, 1914-1923, 2014.

JWS Hayami, SD Waldman, BG Amsden, "Injectable, high modulus and fatigue resistant, composite scaffold for load-bearing soft tissue regeneration," Biomacromolecules 14, 4236-4247, 2013.

I.O. Babasola, M. Rooney, BG Amsden, "Co-release of bioactive VEGF and HGF from liquid injectable poly(5-ethylene ketal ε-caprolactone-co-D,L-lactide)," Molecular Pharmaceutics 10, 4552-4559, 2013.

MC Vyner, L Liu, HD Sheardown, and BG Amsden, "Elastomer crosslink density affects protein adsorption," Biomaterials 34, 9287-9284, 2013.

O.I. Babasola, BG Amsden, "Osmotically driven protein release from liquid injectable polymers based on 5-ethylene ketal ε-caprolactone: potential and mechanism," Eur J Pharm Biopharm 85, 765-772, 2013.

  1. Yu, S. Young, V. Russo, B.G. Amsden, and L.E. Flynn, "Techniques for the isolation of high quality RNA from cells encapsulated in chitosan hydrogels," Tissue Engineering C19, 11, 829-838, 2013.

L.A. Cornacchionne, B. Qi, J.Bianco, Z. Zhou, B.G. Amsden, "Photo-cross-linked poly(ethylene carbonate) elastomers: synthesis, in vivo degradation, and determination of in vivo degradation mechanism," Biomacromolecules 13, 10, 3099-3107, 2012.

D.C. Surrao, S.D. Waldman, and B.G. Amsden, "Biomimetic poly(lactide)-based fibrous scaffolds for ligament tissue engineering,"Acta Biomaterialia 8, 11, 3997-4006, 2012.

  1. Sukarto, C. Yu, LE Flynn, B.G. Amsden, "Co-delivery of adipose-derived stem cells and growth factor-loaded microspheres in RGD-grafted N-methacrylate glycol chitosan gels for focal chondral repair," Biomacromolecules13, 2490-2502, 2012.

O.I. Babasola, J. Bianco, and BG Amsden, "In vivo degradation and tissue response to poly(5-ethylene ketal e-caprolactone-co-D,L-lactide)”," Biomacromolecules 13, 2211-2217, 2012.

D.C. Surrao, J.Y.C. Fan, S.D. Waldman, and B.G. Amsden, "A crimp-like microarchitecture improves tissue production in fibrous ligament scaffolds in response to mechanical stimuli," Acta Biomaterialia 8, 10, 3704-3713, 2012.

  1. Sukarto, BG. Amsden, "Low melting point amphiphilic microspheres for delivery of bone morphogenetic protein-6 and transforming growth factor β-3 in a hydrogel matrix," J Controlled Release158, 23-62, 2012.
  2. Chapanian, MY Tse, SC Pang, and BG Amsden, "Osmotic release of bioactive VEGF from biodegradable elastomer monoliths is the same in vivo as in vitro," J Pharm Sci101, 588-597, 2012 [More information].

O.I. Babasola, BG Amsden, "Surface eroding, liquid injectable polymers based on 5-ethylene ketal ε-caprolactone,"Biomacromolecules 12, 10, 3423-3431, 2011.

JWS Hayami, SD Waldman, BG Amsden, "A photocurable hydrogel-elastomer composite scaffold with bi-continuous morphology for cell encapsulation," Macromolecular Bioscience 12, 1672-83, 2011.

DC Surrao, AA. Khan, AJ. McGregor, JCY Fan, B.G. Amsden, SD Waldman, "Can Microcarrier Expanded Chondrocytes Synthesize Functional Tissue In Vitro," Tissue Engineering A 17, 1959-67, 2011.

AJ McGregor, BG Amsden, SD Waldman, "Chondrocyte repopulation of the zone of death induced by osteochondral harvest,"Osteoarthritis and Cartilage 19, 2, 242-248, 2011.

  1. Chapanian, M.Y. Tse, S.C. Pang, and B.G. Amsden, "Long term in vivo degradation and tissue response to photo-cross-linked elastomers prepared from star-shaped prepolymers of poly(ε-caprolactone-co-D,L-lactide)," J Biomed Mater Res A92A, 830-842, 2010.
  2. Ilagan and B.G. Amsden, "Macroporous photocrosslinked elastomer scaffolds containing microporosity: preparation and in vitro degradation properties," J. Biomed. Mater. Res. A93A, 211-218, 2010.
  3. Hayami, D. Surrao, S.D. Waldman, and B.G. Amsden, "Composite scaffold for ligament tissue engineering," J. Biomed. Mater. Res. A92A, 1407-1420, 2010.
  4. Chapanian and B.G. Amsden, "Osmotically driven protein release from photo-cross-linked elastomers of poly(trimethylene carbonate) and poly(trimethylene carbonate-co-D,L-lactide)," Eur. J. Pharm. Biopharm.74, 172-183, 2010.
  5. Chapanian and B.G. Amsden, "Combined and sequential delivery of bioactive VEGF165 and HGF from poly(trimethylene carbonate) based photo-cross-linked elastomers," J. Controlled Release143, 53-63, 2010.
  6. Amsden and B. Qi, "Anti-atherosclerotic peptide delivery from a photocrosslinkable biodegradable network," Int. J. Pharmaceutics388, 32-39, 2010.
  7. Timbart, MY Tse, SC Pang, and BG Amsden, "Tissue response to, and degradation rate of, photocrosslinked trimethylene carbonate-based elastomers following intramuscular implantation," Materials: Special Issue Advances in Biomaterials3, 2, 1156-1171, 2010.
  8. Amsden, "Liquid, injectable, hydrophobic and biodegradable polymers as drug delivery vehicles," Macromolecular Bioscience10, 8, 825-835, 2010.

A.Hsieh, T Zahir, Y Lapitsky, B. Amsden, W. Wan, MS Shoichet, "Hydrogel/Electrospun Fiber Composites Influence Neural Stem/Progenitor Cell Fate," Soft Matter 6, 10, 2227-2237, 2010.

BG Amsden, L. Timbart, D. Marecak, M.Y. Tse, SC Pang, "VEGF –induced angiogenesis following localized delivery from injectable low viscosity poly(trimethylene carbonate)," J Controlled Release 145, 109-115, 2010.

DC Surrao, JWS Hayami, SD Waldman, BG Amsden, "Self Crimping Electrospun Polymer Fibres," Biomacromolecules 11, 3624-3629, 2010.

  1. Timbart, M.Y. Tse, S.C. Pang, O. Babasola, B.G. Amsden, "Low viscosity poly(trimethylene carbonate) for localized drug delivery: rheological properties and in vivo degradation," Macromolecular Bioscience9, 786-794, 2009.
  2. Ilagan and B.G. Amsden, "Surface modifications of photocrosslinked biodegradable elastomers and their influence on smooth muscle cell adhesion and proliferation," Acta Biomaterialia5, 7, 2429-2440, 2009.
  3. Chapanian, M.Y. Tse, S.C. Pang, and B. Amsden, "Role of oxidation and enzymatic action in the in vivo degradation of trimethylene carbonate based photocrosslinkable elastomers," Biomaterials30, 3, 295-306, 2009 [More information].
  4. Timbart and B.G. Amsden, "Functionalizable biodegradable photocrosslinkable elastomers based on 2-oxepane-1,5-dione," J Polym Sci A Polym Chem46, 24, 8191-8199, 2008 [More information].

B.G. Amsden and A. Lau, "Siloxane based copolymers for use in two-phase partitioning bioreactors," Can J Chem Eng 86, 1-5, 2008 [More information].

  1. Amsden, G.P. Misra, M. Marshall, ND Turner, "Synthesis and characterization of biodegradable networks providing saturated-solution prolonged delivery," J Pharm Sci97, 849-862, 2008 [More information].
  2. Amsden, "Drug delivery from biodegradable elastomers," Expert Opinion on Drug Delivery 5, 175-187, 2008 [More information].
  3. Wang, G Misra, and B. Amsden, "Immobilization of a bone and cartilage stimulating peptide to a synthetic bone graft," J Mater Sci Mater Med19, 2145-2155, 2008 [More information].

D.K. Knight, S. Shapka, and B. Amsden, "Structure, depolymerization, and cytocompatibility evaluation of glycol chitosan," J Biomed Mater Res A 83A, 787-798, 2007 [More information].

  1. Amsden, A. Sukarto, D.K. Knight, and S.N. Shapka, "Methacrylated glycol chitosan as a photopolymerizable biomaterial,"Biomacromolecules8, 12, 3758-3766, 2007 [More information].
  2. Gu, R. Neufeld, and B. Amsden, "Stabilization of bioactive VEGF and potentially other therapeutic proteins during a photo-initiated free radical cross-linking reaction forming biodegradable elastomers," Eur J Pharm Biopharm66, 21-27, 2007 [More information].
  3. Sharifpoor and B. Amsden, "In vitro release of a water-soluble agent from low viscosity biodegradable, injectable oligomers,"Eur J Pharm Biopharm65, 336-345, 2007 [More information].
  4. Gu, RJ Neufeld, B. Amsden, "Sustained release of bioactive therapeutic proteins from a cylindrical biodegradable elastomeric device," J Control Release117, 80-89, 2007 [More information].
  5. Amsden, "Review of osmotic pressure driven release of proteins from monolithic devices," J Pharm Pharmaceut Sci10, 2, 100-114, 2007 [More information].
  6. Amsden, "Curable elastomers: Emerging biomaterialsfor drug delivery and tissue engineering ," Soft Matter3, 11, 1335-1348, 2007 [More information].
  7. Mikhail, S. Sharifpoor, and B. Amsden, "Initiator structure influence on thermal and rheological properties of oligo(e-caprolactone)," J. Biomater. Sci. Polym Edn17, 291-301, 2006 [More information].
  8. Gu, RJ Neufeld, and BG Amsden, "Osmotic driven release kinetics of bioactive therapeutic proteins from a biodegradable elastomer are linear, constant, similar and adjustable," Pharm Res23, 4, 782-789, 2006 [More information].
  9. Zhang and B. Amsden, "Diffusion of vitamin B12 and proteins in semidilute alginate solutions under physiological conditions,"Macromolecules39, 1073-1078, 2006 [More information].
  10. Amsden, M. Y. Tse, N.D. Turner, D.K. Knight, and S.C. Pang, "In vivo degradation behavior of photo-cross-linked star-poly(e-caprolactone-co-D,L-lactide) elastomers," Biomacromolecules7, 365-372, 2006 [More information].
  11. Tomkins, M. Kontopoulou, and B. Amsden, "Preparation and characterization of blends of star-poly(e-caprolactone-co-D,L-lactide) and oligo(e-caprolactone)," J. Biomater. Sci. Polym. Edn.16, 1009-1021, 2005 [More information].
  12. Gu, H.M. Younes, A.O.S. El-Kadi, R. Neufeld, B. Amsden, "Sustained interferon-y delivery from a photocrosslinked biodegradable elastomer," J. Control. Release102, 607-617, 2005 [More information].

B.G. Amsden, G. Misra and F. Gu, "Synthesis and characterization of a photo-crosslinked biodegradable elastomer,"Biomacromolecules 5, 6, 2479-2486, 2004 [More information].

B.G. Amsden, B.G. Stubbe, F. Horkay, S.C. De Smedt, and J. Demeester, "Modeling the swelling pressure of degrading DEX-HEMA hydrogels," J. Polym. Sci. B. Polym. Phys. 42, 3397-3404, 2004 [More information].

  1. Amsden, S. Wang, and U. Wyss, "Synthesis and characterization of thermoset biodegradable elastomers based on star-poly(e-caprolactone-co-D,L-lactide)," Biomacromolecules5, 4, 1399-1404, 2004 [More information].
  2. Gu, B. Amsden, R.J. Neufeld, "Sustained delivery of vascular endothelial growth factor using alginate beads," J. Control. Release96, 463-472, 2004 [More information].
  3. Hatefi, D. Knight, and B. Amsden, "A biodegradable injectable thermoplastic for localized camptothecin delivery," J. Pharm. Sci.93, 1195-1204, 2004 [More information].

H.M. Younes, E. Bravo-Grimaldo, and B. Amsden, "Synthesis, characterization and in vitro degradation of a biodegradable elastomer," Biomaterials 25, 5261-5269, 2004 [More information].

  1. Amsden, A. Hatefi, D. Knight, E. Bravo-Grimaldo, "Development of injectable biodegradable thermoplastic oligomers,"Biomacromolecules5, 637-642, 2004 [More information].
  2. Amsden, "A model for osmotic pressure driven release from cylindrical rubbery polymer matrices," J. Control. Release93, 249-258, 2003 [More information].

B.G. Amsden, J. Bochanysz, and A.J. Daugulis, "Degradation of xenobiotics in a partitioning bioreactor in which the partitioning phase is a polymer," Biotechnol. Bioeng. 84, 399-405, 2003 [More information].

A.J. Daugulis, B.G. Amsden, J. Bochanysz, and A. Kayssi, "Delivery of benzene to Alcaligenes xylosoxidans by solid polymers in a two-phase partitioning bioreactor," Biotech. Letters 25, 1203-1207, 2003 [More information].

Barbara G. Stubbe, Ferenc Horkay, Brian Amsden, Wim E. Hennink, Stefaan C. De Smedt, and Jo Demeester, "Tailoring the swelling pressure of degrading dextran hydroxyethyl methacrylate hydrogels," Biomacromolecules 4, 691-695, 2003 [More information].

  1. Hatefi and B. Amsden, "Camptothecin delivery systems," Pharm. Res.19, 10, 1387-1397, 2002 [More information].
  2. Hatefi and B. Amsden, "Biodegradable injectable in-situ forming drug delivery systems," J. Control. Release80, 9-28, 2002 [More information].
  3. Amsden, "Modeling solute probe diffusion in polymer solutions," Polymer43, 5, 1623-1630, 2002 [More information].

H.M. Younes, and B. Amsden, "Interferon-g therapy: Evaluation of routes of administration and delivery systems," J. Pharm. Sci. 91, 1, 2-17, 2002 [More information].

  1. Amsden, K. Grotheer, and D. Angl, "Influence of polymer Ionization degree on solute diffusion in polyelectrolyte gels,"Macromolecules35, 3179-3183, 2002 [More information].
  2. Amsden, "Diffusion in polyelectrolyte hydrogels: Application of an obstruction-scaling model to solute diffusion in calcium alginate," Macromolecules34, 1430-1435, 2001 [More information].
  3. Amsden, "Constant release from a swollen polyelectrolyte gel," Proceed. Int'l.Symp. Controlled Release of Bioactive Materials, Paris, France750-751, 2000.
  4. Amsden and N. Turner, "Diffusion characteristics of calcium alginate gels," Biotech. Bioeng65, 605-610, 1999 [More information].
  5. Amsden, "The production of uniformly sized polymer microspheres," Pharm. Res.16, 1140-1143, 1999 [More information].

B.G. Amsden, "An obstruction-scaling model for diffusion in homogeneous hydrogels," Macromolecules 32, 874-879, 1999.

B.G. Amsden, "Diffusion within hydrogels. Mechanisms and models," Macromolecules 31, 23, 8382-8395, 1998 [More information].

B.G. Amsden, "Solute diffusion in hydrogels. An examination of the retardation effect," Polymer Gels and Networks 6, 1, 13-43, 1998.

B.G. Amsden and M.F.A. Goosen, "An examination of factors affecting the size, distribution, and release characteristics of polymer microbeads made using electrostatics," J. Control. Release 43, 183-196, 1997.

B.G. Amsden, "Osmotically activated protein release from electrostatically generated polymer microbeads," AIChE Journal 42, 3253-3266, 1996.

A.O. Okhamafe, B. Amsden, W. Chu, and M. Goosen, "Modulation of protein release from chitosan-alginate microcapsules using a pH-sensitive polymer," J. Microencapsulation 13, 497-508, 1996.

  1. G. Amsden and M.F.A. Goosen, "Transdermal delivery of peptide and protein drugs: An overview," AIChE Journal41, 1833-2012, 1995.
  2. Amsden and Y. Cheng, "Generic peptide delivery systems based on osmotically rupturable monoliths," J. Control. Release33, 99-105, 1995.

B.G. Amsden, Y. Cheng, and M. Goosen, "A mechanistic study of the release of osmotically active agents from elastomeric monoliths," J. Controlled Release 30, 21-32, 1994.

B.G. Amsden and Y. Cheng, "Enhanced fraction releasable above percolation threshold from monoliths containing osmotic excipients," J. Control. Release 31, 45-56, 1994.

Polk, B. Amsden, F. DeYao, T. Peng, and M. Goosen, "Chitosan-alginate microcapsules for oral protein drug delivery," J. Pharmaceutical Sciences 84, 178-185, 1994.

  1. Poncelet, B. Bugarski, B. Amsden, J. Zhu, R. Neufeld, and M.F.A. Goosen, "A parallel plate electrostatic droplet generator: parameters affecting microbead size," Applied Microbiology and Biotechnology41, 1994.

Bugarski, B. Amsden, R.J. Neufeld, D. Poncelet, and M.F.A. Goosen, "Effect of electrode geometry and charge on the production of polymer microbeads by electrostatics," Canadian Journal of Chemical Engineering 72, 517-521, 1994.

  1. Zhang, U.P. Wyss, D. Pichora, B. Amsden, and M. Goosen, "Controlled release of albumin from biodegradable poly(DL-lactide) cylinders," J. Control. Release25, 61-69, 1993.
  2. Timbart and B.G. Amsden, "Functionalizable biodegradable photocrosslinkable elastomers based on 2-oxepane-1,5-dione," J Polym Sci A Polym Chem46, 24, 8191-8199.
  3. Sharifpoor and B. Amsden, "Release of a water-soluble agent from low viscosity biodegradable, injectable oligomers is driven by osmotic pressure," Eur J Pharm Biopharm65, 2007, 336-345, [More information].


  1. Mohajeri, BG Amsden, F Chen, “Liquid Injectable Copolymer,” US 16/182,843, October 21, 2021

B.G. Amsden and G.P. Misra, “Degradable Elastomeric Network,”CA2504076C, December 9, 2014.

B.G. Amsden, M.Y. Garcia, I.D. Grant, J.L. Scifert, T.J.N. Smith, “Biphasic calcium phosphate cement for drug delivery,” US8529933B2, Sept 10,2013.

B Amsden, M Garcia, I Grant, J Scifert, T Smith, “Si substituted calcium phosphate cement for drug delivery,” WO 2011017091, 2011/2/11

B.G. Amsden, “Biodegradable Elastomer and Method of Preparing Same,” Canadian Patent 2,385,140 2011.

B.G. Amsden, "Biodegradable Elastomer and Method of Preparing Same," US patent 6,984,393, 2006.

W.L. Hunter, and B.G. Amsden, "Composition and methods of Paclitaxel for treating psoriasis," US patent 6,515,016, 2003.

B.G. Amsden, R. Liggins, "Methods for Microsphere Production," U.S. Patent 6,224,794 B1, 2001.

B.G. Amsden and Y. Cheng, "Polymer-Based Drug Delivery System," U.S. Patent No. 5,626,877, 1997.

B.G. Amsden and Y. Cheng, "Polymer-Based Drug Delivery System," U.S. Patent No. 5,302,397, 1994.


  • Donald and Joan McGeachy Chair in Biomedical Engineering, 2016, 2021
  • Fellow Engineering Institute of Canada, 2020
  • Fellow Biomaterials Science and Engineering, 2016
  • Ontario Centres of Excellence Mind to Market Award, 2006
  • Queen's University Chancellor's Research Award, 2005
  • Province of Ontario Premier's Research Excellence Award, 2003
  • Alberta Heritage Foundation for Medical Research Independent Establishment Grant Award, 1998


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